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The tech-heavy composite rose over 111 points, or 0.9%, helped in part by Tesla, which continues to smash records.
Elon Musk's electric-vehicle maker, which will be added to the S&P 500 on Dec. 21, has seen its market cap soar to $555 billion through Friday.
The S&P 500 also closed at a fresh record rising 0.24%, while the Dow Jones Industrial Average rose over 37 points just below that key 30,000 level reached for the first time in history earlier this week.
DOW, S&P, NASDAQ RISE 2% FOR THE WEEK
All three of the major U.S. averages clocked gains of over 2% for the week.
Americans are spending as Black Friday kicked off the holiday shopping season heading into Cyber Monday. Already, online sales hit a record $5.1 billion, as tracked by Adobe Analytics. Major retailers closed mixed on Friday.
Vaccine news continues to dictate market sentiment.
TickerSecurityLastChangeChange %AZNASTRAZENECA PLC52.61+0.01+0.02%
AstraZeneca was little changed after CEO Pascal Soriot told Bloomberg News that the company will likely conduct a new trial of its COVID-19 vaccine as some participants received incorrect dosages. Other vaccine makers, Pfizer, Moderna and BioNTech, tacked on gains.
Slack Technologies Inc. dipped as traders digest a possible deal with Salesforce.com Inc. Slack shares soared 38% after news of advanced talks between the two companies broke on Wednesday. A deal could be announced, according to reports, early next week valuing slack around $17 billion.
Looking at commodities, West Texas Intermediate crude oil fell 33 cents to $45.25 per barrel, while gold plunged over $21.00 to $1,790 an ounce, losing the key $1,800 support level.