Charlamagne made those comments on Friday after CNN anchor Brooke Baldwin suggested Biden had a solid base among African-Americans.
Biden, he said, "was the vice president to the first black president, so I think it's more bro-ism than anything," Charlamagne said, referring to former President Barack Obama.
He added that Biden, frontrunner for the Democratic presidential nomination, didn't show a lot of support for blacks when he supported the 1994 crime bill.
"I look at Joe Biden and I look at the '94 crime bill and I look at the '88 crack laws — that's not being in support of African-Americans at all," he said.
He also questioned whether Biden was "suffering from that … white entitlement and privilege and ego" after the candidate declined to appear on his show.
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He suggested that Biden may be like an "old-school white male" who acted like he didn't need the people in Charlamagne's audience. "That's not respect," he told CNN on Friday.
Biden was invited to speak on Charlamagne's program — "The Breakfast Club" — but the former vice president decided to send a surrogate instead, according to the radio host.
"Joe Biden has offered to send his surrogate, so that tells me a lot about what Joe Biden thinks about our audience," he said.