(CNN)A fiery crash involving 12 cars and three semis left multiple people dead and at least six others injured in Colorado, authorities said.

The crash occurred on Interstate 70 in the Denver area Thursday evening, according to the Lakewood Police Department. It tweeted that there were “multiple” fatalities, but did not provide the number of people killed, saying authorities are working to put out the fire and match the victims to their vehicles. The priority now is to extinguish the blaze and identify who was in each car, police said. At least six people were transported to hospitals.

Link: Final update for the night on I-70 crash. Highway will remain closed at least overnight. We can confirm that there are multiple fatalities and 6 others taken to local hospitals. https://t.co/PPXN4gz7W2

— Lakewood Police (@LakewoodPDCO) April 26, 2019 The crash started when a speeding semitrailer on the eastbound side of the highway collided with other vehicles, setting off a chain reaction and fire, Agent Ty Countryman of Lakewood Police told CNN affiliate KDVR. The I-70 eastbound traffic was at a standstill because there was another crash farther up the freeway, police said at a news conference. Authorities said the semi rammed into the cars stuck in the traffic from the other crash. Read MoreVideo from the scene showed firefighters spraying water on towering orange flames and burning cars.”This is looking to be one of the worst accidents we’ve had here in Lakewood,” Countryman said. The Denver West Parkway bridge over I-70 got significant structural damage from the fire, authorities said. Both directions of I-70 are closed overnight at the scene of the fire, police said.

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