Infectious disease expert Michael Osterholm warned on Friday of the possibility of “substantial” local and regionalized surges of COVID-19, telling CNN’s Poppy Harlow that “we’re not done with this virus at all.”

Osterholm, the director of the Center for Infectious Disease Research and Policy at the University of Minnesota, doubted another national surge because of the scale of the United States’ vaccination program which to date has seen more than 175 million Americans receive at least one shot.

But Osterholm said more localized surges could occur if the highly transmissible Delta variant took hold in the U.S., where it is now quickly spreading.

The variant first identified in India has already become the dominant strain of the virus in the United Kingdom, where rising cases have forced the delay of easing of lockdown restrictions.

Rochelle Walensky, director of the Centers for Disease Control and Prevention, said Friday the Delta variant will “probably” become the most dominant in America. Osterholm agreed, noting its ability to evade the immunity provided by a single dose of the vaccine.

"We have to know that we’re not done with the virus yet. We have over a hundred counties in this country that have had less than 20% of their population vaccinated. We have states where we’re well below 40% with even a single dose of vaccine in people."–Dr. Michael Osterholm pic.twitter.com/JHdty4Pp7k

— John Tully⚡ (@Tullycast) June 18, 2021

“We have over 100 counties in this country that have had less than 20% of their population vaccinated,” Osterholm told CNN’s Harlow on Friday in a video shared online by Mediaite. “We have states where we’re well below 40% with even a single dose of vaccine in people.”

“So we have a lot of susceptible people out there yet that have been not vaccinated, that, for example, should this Delta variant take over, we’re going to see local and regional surges that are substantial,” he continued.

“I think this is all the more reason why we have to know that we’re not done with the virus yet,” Osterholm added. “We’re surely farther along in this country than other places but we still need to get people vaccinated. And as you know, things have slowed down dramatically in terms of new people getting vaccinated.”

Osterholm recalled similar fears over the Alpha variant, which was first identified in the U.K. and then spread across Europe in January and February. A predicted devastating surge in the U.S. never materialized, though.

“It did become the dominant variant but we didn’t see the big increase in cases,” said Osterholm. “So, I’ve obviously had a note of caution here with regard to the Delta variant, this new one we’re talking about.”

“Maybe the same thing will happen, but maybe it won’t,” he admitted. “And we have to be in our business prepared for the maybe it will happen like it did in England.”

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