The 75th annual Golden Globe Awards kicked off with a red carpet and opening monologue that focused almost entirely on the growing topic of sexual harassment in show business highlighted by the fall of several men in power and the “#MeToo” movement.

Host Seth Meyers took the stage and began by greeting the crowd as “Ladies and remaining gentlemen.”

“It’s 2018, marijuana is finally allowed and sexual harassment finally isn’t. It’s going to be a good year,” he joked.

The Globes had long been the stomping grounds of disgraced mogul Harvey Weinstein, whose downfall precipitated allegations against James Toback, Kevin Spacey and many others. Weinstein presided over two decades of Globes winners and was well-known for his manipulation of the Hollywood Foreign Press Association, the 89-member group that puts on the Globes.

“Harvey Weinstein isn’t here tonight because, well, I’ve heard rumors he’s crazy and difficult to work with,” Meyers said. “Don’t worry because he’ll be back in 20 year when he becomes the first person ever booed during the In Memoriam.”

Meyers also went after Kevin Spacey, who was accused by several actors of sexual assault.

“Despite everything that happened this year, the show goes on,” Meyers said. “For example, I was happy to hear they were going to do another season of ‘House of Cards.’ Is Christopher Plummer available for that too? I hope he can do a Southern accent because Kevin Spacey sure couldn’t.”

The joke, a reference to Plummer replacing Spacey in the film “All the Money in the World,” was met with awkward gasps from the audience and Meyers quickly quipped, “Oh, is that too mean to Kevin Spacey?”

President Trump was also a talking point for the late night host. 

“We’re all here at the courtesy of the Hollywood Foreign Press Association,” he said. ”A string of three words that could not have been better designed to infuriate our president. The only name that would make him angrier would be the Hillary Mexico Salad Associated.”

75th Golden Globe Awards – Arrivals – Beverly Hills, California, U.S., 07/01/2018 – Actress Nicole Kidman. REUTERS/Mario Anzuoni - HP1EE1803GIMA

Reuters  (Nicole Kidman took home the first award at the 2018 Golden Globe Awards)

The star ended his speech on a serious note saying, “People in this room worked really hard to get here but it’s clearer now than ever before, the women had to work harder. So thank you for all that you do. I look forward to seeing you lead us into whatever some next.”

Before the show started, many female stars arrived on the red carpet with activist guests — Michelle Williams with #MeToo founder Tarana Burke, Meryl Streep and domestic workers advocate Ai-jen Poo, Laura Dern and farmworker advocate Monica Ramirez — as part of the larger effort to keep the Globes spotlight trained on the sexual harassment and assault scandals that have roiled Hollywood and other industries.

Following Meyers’ intro, the show moved on with Gal Gadot and Dwayne Johnson awarding Nicole Kidman with the first win of the night for best performance by an actress in a limited series or a motion picture made for television for her role on “Big Little Lies.”

Hollywood’s awards season is seen as wide open, but the early returns Sunday were good for one of the leading nominees: the revenge comedy “Three Billboards Outside Ebbing, Missouri.” Sam Rockwell won for best supporting actor.

Tommy Wiseau attends the 75th annual Golden Globe Awards at the Beverly Hilton Hotel on Sunday, Jan. 7, 2018, in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP)

AP  (“The Room” producer, writer and star, Tommy Wiseau took the stage with James Franco at the 2018 Golden Globe Awards.)

“The Handmaid’s Tale” beat out dramas such as “Game of Thrones” and “Stranger Things” to take home the award for best television drama series. Adding to the Hulu original series’ accolades was Elisabeth Moss, who won best performance by an actress in a television drama series for her role as June Osborne. Meanwhile, Sterling K. Brown earned himself an award for best performance by an actor in a television drama series for his role in NBC’s “This is Us.”

James Franco’s unexpected breakout hit “The Disaster Artist” earned him the award for best performance by an actor in a motion picture, musical or comedy. The star brought Tommy Wiseau, the real man behind his character in the film, up to stage with him for a special thanks noting that it was the enigmatic actor, writer and producer’s frustration with being stuck in traffic because of the Golden Globes years ago that prompted him to write the now-infamous film “The Room.”

“Coco” the animated Disney and Pixar film about the Mexican holiday Dia de los Muertos achieved the Golden Globe award for best animated motion picture.

Aziz Ansari won the coveted award for best comedy television series for his show “Master of None,” which debuted its second season on Netflix last year. He beat out other nominees such as “Black-ish” and the “Will and Grace” revival.

The show honored talk show host, actress, producer and general household name Oprah Winfrey with the Cecil B. DeMille award for her contributions to the world of entertainment throughout her career. In her very impassioned acceptance speech, she refocused the show on the “#MeToo” movement. She noted that she is the first black woman to win this award, which she hoped may inspire young girls.

“I want all the girls watching here now to know that a new day is on the horizon,” she said. “When that new day finally dawns, it will be because of a lot of magnificent women, many of whom are right here in this room tonight, and some pretty phenomenal men, fighting hard to make sure they become the leaders who take us to the time when nobody ever has to say ‘me too’ again.

After that, Ron Howard and Natalie Portman took the stage to announce the nominees and winner of best director. However, before the names were read, Portman took the opportunity to note that all of the nominees were men.

Guillermo del Toro took home the award for best director for his work on “The Shape of Water.”

The Associated Press contributed to this report.

You can find Sasha Savitsky on Twitter @SashaFB.

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