Hong Kong (CNN)The death toll from the Wuhan coronavirus has topped 100, with more than 4,500 cases confirmed across China, as US authorities warned against all “non-essential” travel to China.

Authorities in Hubei, the Chinese province at the center of the outbreak, said an additional 1,300 cases had been confirmed, bringing the total in the region to over 2,700. The majority of those are still in hospital, with more than 125 in critical condition. Elsewhere in China, cases have been confirmed in every province and territory except for Tibet, which this week announced the indefinite closure of all tourist attractions and a mandatory two-week quarantine for all travelers entering the region. On Monday, the US Centers for Disease Control (CDC) issued a level 3 alert warning against “all nonessential travel to China.” — its highest alert on a scale of 1 to 3.”There is an ongoing outbreak of respiratory illness caused by a novel (new) coronavirus that can be spread from person to person,” the CDC said in a statement, warning “there is limited access to adequate medical care in affected areas.” Read MoreWorldwide concern More than a dozen countries around the world have confirmed cases of the Wuhan virus, as authorities struggle to stop its spread. Across Asia, numerous countries have put in extra screening at airports and warned citizens to avoid travel to China. To China’s north, neighboring Mongolia has imposed stringent border checks on travelers coming into the country, while the semi-autonomous city of Hong Kong in the south has banned all visitors from Wuhan, amid calls for tighter controls on travel from the mainland. Indonesia and the Philippines have both introduced extra restrictions on Chinese tourists, while Japan has upgraded its response, allowing authorities to “force the suspicious cases for hospitalization and testing.” Speaking at a meeting with United Nations Secretary General Antonio Guterres Monday, China’s ambassador to the UN said the country has “full capability and confidence in winning the battle against the epidemic.””Putting the interests of the people first, China has taken rapid and strong measures, putting in place a nationwide prevention and control mechanism,” Ambassador Zhang Jun said. “China has been working with the international community in the spirit of openness, transparency and scientific coordination. With a great sense of responsibility, China is sparing no effort in curbing the spread of disease and saving lives. Now is a crucial moment, and China has full capability and confidence in winning the battle against the epidemic.”Some 60 million people have been placed under travel restrictions in Hubei, with almost all movement in and out of Wuhan itself stopped and much of the city on lockdown. Officials have also cracked down on the trade of wild animals, after the Wuhan coronavirus was linked to a seafood market selling exotic live mammals, including bats and civet cats, which have previously been linked to the 2003 SARS outbreak. Rapid spread The first cases of the coronavirus were detected in Wuhan in mid-December. Since then the number of confirmed cases has increased a thousandfold, and infections have been reported worldwide. Hospitals in Wuhan are already massively overstretched, and hundreds of emergency medical personnel have been dispatched to the city to help out. Two new hospitals are also being built on the city’s outskirts, due to be operational by next week. Wuhan and Hubei officials have faced criticism for apparently downplaying the danger of the virus in the early weeks of the outbreak. There was a marked shift in the handling of the crisis once the national government got involved on January 22. woDespite the colossal effort — and potential social and economic cost — of effectively quarantining Hubei, it appears that this has come too late to stop the virus’ spread. By the time Wuhan introduced even basic screening of travelers leaving the city, the virus had been reported in Japan, Thailand and South Korea, and spread to most of the rest of China. Part of the problem is that the virus can apparently be spread before symptoms appear, according to China’s health minister, Ma Xiaowei. “It means the infection is much more contagious than we originally thought,” William Schaffner, a longtime adviser to the US Centers for Disease Control and Prevention, told CNN. “This is worse than we anticipated.”While the current outbreak does not appear to be as deadly as SARS, which killed over 700 people worldwide, it may be spreading more rapidly. That could be due to being more contagious, or the increased interconnectedness of both China and the world than in 2003. As of mid-March 2003, roughly a month after the World Health Organization (WHO) was alerted to SARS by Chinese authorities, and three months after the first cases were detected in China, the number of confirmed cases worldwide stood at around 3,200, with 159 confirmed deaths. Flight crews wearing masks arrive at the Toronto Pearson Airport in Toronto, Canada, on Sunday, January 26.Flight crews wearing masks arrive at the Toronto Pearson Airport in Toronto, Canada, on Sunday, January 26. Photos: The Wuhan coronavirus outbreakFlight crews wearing masks arrive at the Toronto Pearson Airport in Toronto, Canada, on Sunday, January 26.Hide Caption 1 of 26A man wearing a face mask sits on a bench as he waits on a platform for a MTR underground metro train in Hong Kong on January 27.A man wearing a face mask sits on a bench as he waits on a platform for a MTR underground metro train in Hong Kong on January 27. Photos: The Wuhan coronavirus outbreakA man wearing a face mask sits on a bench as he waits on a platform for a MTR underground metro train in Hong Kong on January 27.Hide Caption 2 of 26Police officers stand in front of the Tiananmen Gate in Beijing on Sunday, January 26.Police officers stand in front of the Tiananmen Gate in Beijing on Sunday, January 26. Photos: The Wuhan coronavirus outbreakPolice officers stand in front of the Tiananmen Gate in Beijing on Sunday, January 26.Hide Caption 3 of 26A person wears a protective mask, goggles and coat as he stands in a nearly empty street in Beijing on January 26.A person wears a protective mask, goggles and coat as he stands in a nearly empty street in Beijing on January 26. Photos: The Wuhan coronavirus outbreakA person wears a protective mask, goggles and coat as he stands in a nearly empty street in Beijing on January 26.Hide Caption 4 of 26Medical staff members bring a patient to the Wuhan Red Cross Hospital on Saturday, January 25.Medical staff members bring a patient to the Wuhan Red Cross Hospital on Saturday, January 25. Photos: The Wuhan coronavirus outbreakMedical staff members bring a patient to the Wuhan Red Cross Hospital on Saturday, January 25.Hide Caption 5 of 26People wear protective masks as they walk under Lunar New Year decorations in Beijing on January 25.People wear protective masks as they walk under Lunar New Year decorations in Beijing on January 25. Photos: The Wuhan coronavirus outbreakPeople wear protective masks as they walk under Lunar New Year decorations in Beijing on January 25.Hide Caption 6 of 26Construction workers begin to work on a special hospital in Wuhan, China, to deal with the coronavirus outbreak on Friday, January 24.Construction workers begin to work on a special hospital in Wuhan, China, to deal with the coronavirus outbreak on Friday, January 24. Photos: The Wuhan coronavirus outbreakConstruction workers begin to work on a special hospital in Wuhan, China, to deal with the coronavirus outbreak on Friday, January 24.Hide Caption 7 of 26Dr. Allison Arwady, commissioner of the Chicago Department of Public Health, speaks to reporters on January 24 about <a href="https://www.cnn.com/2020/01/24/health/wuhan-coronavirus-chicago-cdc/index.html" target="_blank">a patient in Chicago</a> who has been diagnosed with the coronavirus. The patient is the second in the United States to be diagnosed with the illness. Dr. Allison Arwady, commissioner of the Chicago Department of Public Health, speaks to reporters on January 24 about <a href="https://www.cnn.com/2020/01/24/health/wuhan-coronavirus-chicago-cdc/index.html" target="_blank">a patient in Chicago</a> who has been diagnosed with the coronavirus. The patient is the second in the United States to be diagnosed with the illness. Photos: The Wuhan coronavirus outbreakDr. Allison Arwady, commissioner of the Chicago Department of Public Health, speaks to reporters on January 24 about a patient in Chicago who has been diagnosed with the coronavirus. The patient is the second in the United States to be diagnosed with the illness. Hide Caption 8 of 26A couple, wearing protective masks, kisses goodbye as they travel for the Lunar New Year holidays, at Beijing West Railway Station in Beijing. Chinese authorities rapidly expanded a mammoth quarantine effort aimed at containing a deadly contagion on January 24 to 13 cities and a staggering 41 million people, as nervous residents were checked for fevers and the death toll climbed.A couple, wearing protective masks, kisses goodbye as they travel for the Lunar New Year holidays, at Beijing West Railway Station in Beijing. Chinese authorities rapidly expanded a mammoth quarantine effort aimed at containing a deadly contagion on January 24 to 13 cities and a staggering 41 million people, as nervous residents were checked for fevers and the death toll climbed. Photos: The Wuhan coronavirus outbreakA couple, wearing protective masks, kisses goodbye as they travel for the Lunar New Year holidays, at Beijing West Railway Station in Beijing. Chinese authorities rapidly expanded a mammoth quarantine effort aimed at containing a deadly contagion on January 24 to 13 cities and a staggering 41 million people, as nervous residents were checked for fevers and the death toll climbed.Hide Caption 9 of 26Tourists purchase masks at Narita International Airport on January 24, in Narita, Japan, as they prepare to return to China. Tourists purchase masks at Narita International Airport on January 24, in Narita, Japan, as they prepare to return to China. Photos: The Wuhan coronavirus outbreakTourists purchase masks at Narita International Airport on January 24, in Narita, Japan, as they prepare to return to China. Hide Caption 10 of 26Workers manufacture protective face masks in a factory in China's Hebei Province on Thursday, January 23. Face masks stocks are running low following the outbreak of coronavirus.Workers manufacture protective face masks in a factory in China's Hebei Province on Thursday, January 23. Face masks stocks are running low following the outbreak of coronavirus. Photos: The Wuhan coronavirus outbreakWorkers manufacture protective face masks in a factory in China’s Hebei Province on Thursday, January 23. Face masks stocks are running low following the outbreak of coronavirus.Hide Caption 11 of 26An employee sprays disinfectant on a train as a precaution against a new coronavirus at Suseo Station in Seoul, South Korea, on Friday, January 24. An employee sprays disinfectant on a train as a precaution against a new coronavirus at Suseo Station in Seoul, South Korea, on Friday, January 24. Photos: The Wuhan coronavirus outbreakAn employee sprays disinfectant on a train as a precaution against a new coronavirus at Suseo Station in Seoul, South Korea, on Friday, January 24. Hide Caption 12 of 26Passengers wear protective masks at a Beijing railway station on Thursday, January 23. Authorities in the Chinese capital have canceled all large-scale New Year celebrations to contain the spread of the Wuhan coronavirus.Passengers wear protective masks at a Beijing railway station on Thursday, January 23. Authorities in the Chinese capital have canceled all large-scale New Year celebrations to contain the spread of the Wuhan coronavirus. Photos: The Wuhan coronavirus outbreakPassengers wear protective masks at a Beijing railway station on Thursday, January 23. Authorities in the Chinese capital have canceled all large-scale New Year celebrations to contain the spread of the Wuhan coronavirus.Hide Caption 13 of 26A woman rides an electric bicycle on January 22 in Wuhan, China. The city where the outbreak began is under partial lockdown.A woman rides an electric bicycle on January 22 in Wuhan, China. The city where the outbreak began is under partial lockdown. Photos: The Wuhan coronavirus outbreakA woman rides an electric bicycle on January 22 in Wuhan, China. The city where the outbreak began is under partial lockdown.Hide Caption 14 of 26Medical staff transfers a patient at Hospital of Wuhan Red Cross Society, January 23.Medical staff transfers a patient at Hospital of Wuhan Red Cross Society, January 23. Photos: The Wuhan coronavirus outbreakMedical staff transfers a patient at Hospital of Wuhan Red Cross Society, January 23.Hide Caption 15 of 26People in Guangzhou, China, wear protective masks on January 22.People in Guangzhou, China, wear protective masks on January 22. Photos: The Wuhan coronavirus outbreakPeople in Guangzhou, China, wear protective masks on January 22.Hide Caption 16 of 26People go through a checkpoint in Guangzhou on January 22.People go through a checkpoint in Guangzhou on January 22. Photos: The Wuhan coronavirus outbreakPeople go through a checkpoint in Guangzhou on January 22.Hide Caption 17 of 26Shoppers wear masks in a Wuhan market on January 23.Shoppers wear masks in a Wuhan market on January 23. Photos: The Wuhan coronavirus outbreakShoppers wear masks in a Wuhan market on January 23.Hide Caption 18 of 26Medical staff of Union Hospital, affiliated with the Tongji Medical College of Huazhong University of Science and Technology, attend a gathering to form an "assault team" in the fight against pneumonia caused by the Wuhan coronavirus on January 22.Medical staff of Union Hospital, affiliated with the Tongji Medical College of Huazhong University of Science and Technology, attend a gathering to form an "assault team" in the fight against pneumonia caused by the Wuhan coronavirus on January 22. Photos: The Wuhan coronavirus outbreakMedical staff of Union Hospital, affiliated with the Tongji Medical College of Huazhong University of Science and Technology, attend a gathering to form an “assault team” in the fight against pneumonia caused by the Wuhan coronavirus on January 22.Hide Caption 19 of 26Passengers from overseas are checked by a thermography device on January 23 at the Kansai International Airport in Osaka, Japan.Passengers from overseas are checked by a thermography device on January 23 at the Kansai International Airport in Osaka, Japan. Photos: The Wuhan coronavirus outbreakPassengers from overseas are checked by a thermography device on January 23 at the Kansai International Airport in Osaka, Japan.Hide Caption 20 of 26Health officials hold a press conference in Beijing on January 22 following the spread of pneumonia caused by the coronavirus.Health officials hold a press conference in Beijing on January 22 following the spread of pneumonia caused by the coronavirus. Photos: The Wuhan coronavirus outbreakHealth officials hold a press conference in Beijing on January 22 following the spread of pneumonia caused by the coronavirus.Hide Caption 21 of 26People wear marks while shopping for vegetables in a market in Wuhan on January 23.People wear marks while shopping for vegetables in a market in Wuhan on January 23. Photos: The Wuhan coronavirus outbreakPeople wear marks while shopping for vegetables in a market in Wuhan on January 23.Hide Caption 22 of 26A militia member checks the body temperature of a driver in Wuhan on January 23.A militia member checks the body temperature of a driver in Wuhan on January 23. Photos: The Wuhan coronavirus outbreakA militia member checks the body temperature of a driver in Wuhan on January 23.Hide Caption 23 of 26Passengers wear masks as they arrive at the Ninoy Aquino International Airport in Manila, Philippines, on January 23.Passengers wear masks as they arrive at the Ninoy Aquino International Airport in Manila, Philippines, on January 23. Photos: The Wuhan coronavirus outbreakPassengers wear masks as they arrive at the Ninoy Aquino International Airport in Manila, Philippines, on January 23.Hide Caption 24 of 26A customer holds boxes of particulate respirators at a pharmacy in Hong Kong on January 23.A customer holds boxes of particulate respirators at a pharmacy in Hong Kong on January 23. Photos: The Wuhan coronavirus outbreakA customer holds boxes of particulate respirators at a pharmacy in Hong Kong on January 23.Hide Caption 25 of 26Passengers wear masks at the high-speed train station in Hong Kong on January 23.Passengers wear masks at the high-speed train station in Hong Kong on January 23. Photos: The Wuhan coronavirus outbreakPassengers wear masks at the high-speed train station in Hong Kong on January 23.Hide Caption 26 of 2605 wuhan coronavirus 012601 coronavirus 012702 coronavirus beijing 012601 coronavirus beijing 012604b coronavirus 0125 wuhan COPY01 coronavirus 012501 coronavirus 012404 coronavirus 05 coronavirus 0124 beijing 06 conranvirus japan02 coronavirus 0124 RESTRICTED01 coronavirus 012401 coronavirus 02 coronaviruscoronavirus 0123 RESTRICTED04 coronavirus RESTRICTED05 coronavirus RESTRICTED06 coronavirus07 coronavirus RESTRICTED08 coronavirus09 coronavirus RESTRICTED10 coronavirus11 coronavirus RESTRICTED12 coronavirus13 coronavirus RESTRICTED14 coronavirus RESTRICTEDGrowing fearsFears of the virus’ spread have led to calls for increased action in multiple countries and territories, not least in Hong Kong, where memories of SARS still run deep. On Tuesday, the city’s government announced that government workers would be encouraged to work from home when the Lunar New Year holiday ends on Wednesday. The directive, which excluded emergency service workers and people who work for essential public services, urged the private sector to enforce similar arrangements.The move follows calls from one of the city’s leading health experts for “substantial draconian measures” to limit population mobility in order to rein in the virus. Speaking at a news conference Monday, Gabriel Leung, chair of public health medicine at the University of Hong Kong, warned that the number of cases could potentially double every six days in the absence of decisive government action. “This epidemic is growing at quite a fast rate and it’s accelerating,” said Leung, who is also the founding director of the WHO Collaborating Center for Infection Disease Epidemiology and Control in Hong Kong. He predicted the actual number of cases — including those who are incubating the virus but not yet showing symptoms — could be 10 times what has been reported. Leung’s team modeled two scenarios — one with a population quarantine as has been seen in Wuhan and one without — but found more or less identical results, because the virus has already spread to other major population centers in China, which could soon see their own self-sustaining epidemics. Leung said the findings had concerned the team enough that it felt the need to alert the authorities and the public, predicting a peak of cases between April and May. He added people need to prepare for a potential global pandemic — though “not a certainty by any stretch of the imagination … we must prepare better for it,” he said.There have been numerous calls within Hong Kong for the city to close its border with mainland China, and attempts to convert unoccupied apartment buildings in the northern town of Fanling to a quarantine center were met by fierce protests, eventually forcing them to be abandoned.

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